Ultrasound imaging is one of the most widely used diagnostic modalities, offering real-time, radiation-free assessment across diverse clinical domains. However, interpretation of ultrasound images remains challenging due to high noise levels, operator dependence, and limited field of view, resulting in substantial inter-observer variability. Current Deep Learning approaches are hindered by the scarcity of large labeled datasets and the domain gap between general and sonographic images, which limits the transferability of models pretrained on non-medical data. To address these challenges, we introduce the Ultrasound Self-Supervised Foundation Model with Masked Autoencoding (USF-MAE), the first large-scale self-supervised MAE framework pretrained exclusively on ultrasound data. The model was pre-trained on 370,000 2D and 3D ultrasound images curated from 46 open-source datasets, collectively termed OpenUS-46, spanning over twenty anatomical regions. This curated dataset has been made publicly available to facilitate further research and reproducibility. Using a Vision Transformer encoder-decoder architecture, USF-MAE reconstructs masked image patches, enabling it to learn rich, modality-specific representations directly from unlabeled data. The pretrained encoder was fine-tuned on three public downstream classification benchmarks: BUS-BRA (breast cancer), MMOTU-2D (ovarian tumors), and GIST514-DB (gastrointestinal stromal tumors). Across all tasks, USF-MAE consistently outperformed conventional CNN and ViT baselines, achieving F1-scores of 81.6%, 79.6%, and 82.4%, respectively. Despite not using labels during pretraining, USF-MAE approached the performance of the supervised foundation model UltraSam on breast cancer classification and surpassed it on the other tasks, demonstrating strong cross-anatomical generalization.

Background and objective Early diagnosis of gastric diseases is crucial to prevent fatal outcomes. Although histopathologic examination remains the diagnostic gold standard, it is performed entirely manually, making evaluations labor-intensive and prone to variability among pathologists. Critical findings may be missed, and lack of standard procedures reduces consistency. These limitations highlight the need for automated, reliable, and efficient methods for gastric tissue analysis. Methods In this study, a novel hybrid model named CoAtNeXt was proposed for the classification of gastric tissue images. The model is built upon the CoAtNet architecture by replacing its MBConv layers with enhanced ConvNeXtV2 blocks. Additionally, the Convolutional Block Attention Module (CBAM) is integrated to improve local feature extraction through channel and spatial attention mechanisms. The architecture was scaled to achieve a balance between computational efficiency and classification performance. CoAtNeXt was evaluated on two publicly available datasets, HMU-GC-HE-30K for eight-class classification and GasHisSDB for binary classification, and was compared against 10 Convolutional Neural Networks (CNNs) and ten Vision Transformer (ViT) models. Results CoAtNeXt achieved 96.47% accuracy, 96.60% precision, 96.47% recall, 96.45% F1 score, and 99.89% AUC on HMU-GC-HE-30K. On GasHisSDB, it reached 98.29% accuracy, 98.07% precision, 98.41% recall, 98.23% F1 score, and 99.90% AUC. It outperformed all CNN and ViT models tested and surpassed previous studies in the literature. Conclusion Experimental results show that CoAtNeXt is a robust architecture for histopathological classification of gastric tissue images, providing performance on binary and multiclass. Its highlights its potential to assist pathologists by enhancing diagnostic accuracy and reducing workload.

Background: Gastric neoplasm, primarily adenocarcinoma, is an aggressive cancer with high mortality, often diagnosed late, leading to complications like metastasis. Effective drug combinations are vital to address disease heterogeneity, enhance efficacy, reduce resistance, and improve patient outcomes. Methods: The RAIN method integrated Graph SAGE to propose drug combinations, using a graph model with p-value-weighted edges connecting drugs, genes, and proteins. NLP and systematic literature review (PubMed, Scopus, etc.) validated proposed drugs, followed by network meta-analysis to assess efficacy, implemented in Python. Results: Oxaliplatin, fluorouracil, and trastuzumab were identified as effective, supported by 61 studies. Fluorouracil alone had a p-value of 0.0229, improving to 0.0099 with trastuzumab, and 0.0069 for the triple combination, indicating superior efficacy. Conclusion: The RAIN method, combining AI and network meta-analysis, effectively identifies optimal drug combinations for gastric neoplasm, offering a promising strategy to enhance treatment outcomes and guide health policy.

Gastric cancer is one of the most commonly diagnosed cancers and has a high mortality rate. Due to limited medical resources, developing machine learning models for gastric cancer recognition provides an efficient solution for medical institutions. However, such models typically require large sample sizes for training and testing, which can challenge patient privacy. Federated learning offers an effective alternative by enabling model training across multiple institutions without sharing sensitive patient data. This paper addresses the limited sample size of publicly available gastric cancer data with a modified data processing method. This paper introduces FedSAF, a novel federated learning algorithm designed to improve the performance of existing methods, particularly in non-independent and identically distributed (non-IID) data scenarios. FedSAF incorporates attention-based message passing and the Fisher Information Matrix to enhance model accuracy, while a model splitting function reduces computation and transmission costs. Hyperparameter tuning and ablation studies demonstrate the effectiveness of this new algorithm, showing improvements in test accuracy on gastric cancer datasets, with FedSAF outperforming existing federated learning methods like FedAMP, FedAvg, and FedProx. The framework's robustness and generalization ability were further validated across additional datasets (SEED, BOT, FashionMNIST, and CIFAR-10), achieving high performance in diverse environments.

The incidence of gastrointestinal cancers remains significantly high, particularly in China, emphasizing the importance of accurate prognostic assessments and effective treatment strategies. Research shows a strong correlation between abdominal muscle and fat tissue composition and patient outcomes. However, existing manual methods for analyzing abdominal tissue composition are time-consuming and costly, limiting clinical research scalability. To address these challenges, we developed an AI-driven tool for automated analysis of abdominal CT scans to effectively identify and segment muscle, subcutaneous fat, and visceral fat. Our tool integrates a multi-view localization model and a high-precision 2D nnUNet-based segmentation model, demonstrating a localization accuracy of 90% and a Dice Score Coefficient of 0.967 for segmentation. Furthermore, it features an interactive interface that allows clinicians to refine the segmentation results, ensuring high-quality outcomes effectively. Our tool offers a standardized method for effectively extracting critical abdominal tissues, potentially enhancing the management and treatment for gastrointestinal cancers. The code is available at https://github.com/NanXinyu/AI-Tool4Abdominal-Seg.git}{https://github.com/NanXinyu/AI-Tool4Abdominal-Seg.git.

The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via self-supervised learning (SSL). However, translating these advancements to address complex clinical challenges at the patient and slide level remains constrained by limited clinical data in disease-specific cohorts, especially for rare clinical conditions. We propose TITAN, a multimodal whole slide foundation model pretrained using 335,645 WSIs via visual self-supervised learning and vision-language alignment with corresponding pathology reports and 423,122 synthetic captions generated from a multimodal generative AI copilot for pathology. Without any finetuning or requiring clinical labels, TITAN can extract general-purpose slide representations and generate pathology reports that generalize to resource-limited clinical scenarios such as rare disease retrieval and cancer prognosis. We evaluate TITAN on diverse clinical tasks and find that TITAN outperforms both ROI and slide foundation models across machine learning settings such as linear probing, few-shot and zero-shot classification, rare cancer retrieval and cross-modal retrieval, and pathology report generation.

The global surge in the cases of gastric cancer has prompted an investigation into the potential of gut microbiota as a predictive marker for the disease. The alterations in gut diversity are suspected to be associated with an elevated risk of gastric cancer. This paper delves into finding the correlation between gut microbiota and gastric cancer, focusing on patients who have undergone total and subtotal gastrectomy. Utilizing data mining and statistical learning methods, an analysis was conducted on 16S-RNA sequenced genes obtained from 96 participants with the aim of identifying specific genera of gut microbiota associated with gastric cancer. The study reveals several prominent bacterial genera that could potentially serve as biomarkers assessing the risk of gastric cancer. These findings offer a pathway for early risk assessment and precautionary measures in the diagnosis of gastric cancer. The intricate mechanisms through which these gut microbiotas influence gastric cancer progression warrant further investigation. This research significantly aims to contribute to the growing understanding of the gut-cancer axis and its implications in disease prediction and prevention.

Abstract-- In this paper, to collectively address the existing limitations on endoscopic diagnosis of Advanced Gastric Cancer (AGC) Tumors, for the first time, we propose (i) utilization and evaluation of our recently developed Vision-based Tactile Sensor (VTS), and (ii) a complementary Machine Learning (ML) algorithm for classifying tumors using their textural features. Leveraging a seven DoF robotic manipulator and unique custom-designed and additively-manufactured realistic AGC tumor phantoms, we demonstrated the advantages of automated data collection using the VTS addressing the problem of data scarcity and biases encountered in traditional ML-based approaches. Our synthetic-data-trained ML model was successfully evaluated and compared with traditional ML models utilizing various statistical metrics even under mixed morphological characteristics and partial sensor contact. I. INTRODUCTION Gastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide and the fourth leading cause of cancerrelated mortality [1]. A major contributor to this challenge is the fact that a substantial portion -- up to 62% -- of GC cases are detected at advanced stages, contributing to poorer overall survival rates compared to cases identified at early stages [2].

Artificial intelligence has worked its way into numerous business sectors under the guise of improving efficiency, but in the medical field it promises to do even more: save lives. AI Medical Service, a Tokyo-based startup developing an AI-based endoscopic diagnostic support system, is convinced of the technology's capabilities and aims to prove its effectiveness. Gastrointestinal cancers are a major cause of cancer death worldwide -- they account for 1 in 3 such deaths globally -- and the startup says this is largely due to an inability to detect them at an early stage.

Classifying hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is a critical step in treatment selection and prognosis evaluation for patients with liver diseases. Traditional histopathological diagnosis poses challenges in this context. In this study, we introduce a novel polarization and radiomics feature fusion network, which combines polarization features obtained from Mueller matrix images of liver pathological samples with radiomics features derived from corresponding pathological images to classify HCC and ICC. Our fusion network integrates a two-tier fusion approach, comprising early feature-level fusion and late classification-level fusion. By harnessing the strengths of polarization imaging techniques and image feature-based machine learning, our proposed fusion network significantly enhances classification accuracy. Notably, even at reduced imaging resolutions, the fusion network maintains robust performance due to the additional information provided by polarization features, which may not align with human visual perception. Our experimental results underscore the potential of this fusion network as a powerful tool for computer-aided diagnosis of HCC and ICC, showcasing the benefits and prospects of integrating polarization imaging techniques into the current image-intensive digital pathological diagnosis. We aim to contribute this innovative approach to top-tier journals, offering fresh insights and valuable tools in the fields of medical imaging and cancer diagnosis. By introducing polarization imaging into liver cancer classification, we demonstrate its interdisciplinary potential in addressing challenges in medical image analysis, promising advancements in medical imaging and cancer diagnosis.